Product Details
MT-1 — Linear Melanocortin Receptor Agonist
MT-1 (Melanotan I) is a synthetic linear tridecapeptide analog of alpha-melanocyte stimulating hormone (α-MSH), featuring amino acid substitutions that enhance metabolic stability while maintaining the linear peptide structure. Unlike cyclic analogs such as MT-2, the linear structure of MT-1 provides a more selective melanocortin receptor binding profile, making it a valuable tool for MC receptor subtype studies.
Mechanism of Action
MT-1 demonstrates preferential binding to MC1R, the melanocortin receptor subtype primarily responsible for eumelanin synthesis in melanocytes. Upon MC1R activation, the Gs/cAMP/PKA signaling cascade phosphorylates CREB, which upregulates MITF transcription and downstream melanogenic enzymes including tyrosinase, TRP-1, and TRP-2. This targeted MC1R profile distinguishes MT-1 from non-selective melanocortin agonists that simultaneously activate MC3R-MC5R.
Research Applications
- MC1R-selective melanocortin signaling studies
- Melanogenesis and eumelanin biosynthesis research
- Melanocyte biology and pigmentation mechanisms
- Comparative studies with cyclic melanocortin analogs
- Photoprotection and UV response pathway research
Product Specifications
- Quantity: 10mg per vial
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
Not for human use. For research use only.
Stacey Brady verified owner
Fast delivery and product arrived in perfect shape.
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Good stuff.
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Great stuff.
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Excellent experience from order to delivery.
Alex Spitler verified owner
Great product.
Bryan W. verified owner
Works like it should, with careful packaging.
Robert L. verified owner
My one stop shop for research compounds.