Product Details
KPV — Anti-Inflammatory Tripeptide
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment derived from alpha-melanocyte stimulating hormone (α-MSH). Despite being only three amino acids in length, KPV retains the potent anti-inflammatory activity of its parent molecule while being small enough to resist enzymatic degradation and penetrate tissues efficiently. This makes KPV one of the most targeted anti-inflammatory peptides available for research.
Mechanism of Action
KPV exerts anti-inflammatory effects through multiple mechanisms: it inhibits NF-κB nuclear translocation by preventing IκB-α phosphorylation, reduces pro-inflammatory cytokine production (IL-1β, IL-6, TNF-α), and modulates inflammatory cell migration. KPV also interacts with melanocortin receptors, though its anti-inflammatory activity appears partially independent of classical MC receptor binding. Research has demonstrated its ability to cross intestinal epithelial barriers, making it valuable for mucosal inflammation studies.
Research Applications
- NF-κB pathway inhibition and inflammatory signaling
- Mucosal healing and intestinal barrier function
- Cytokine modulation (IL-1β, IL-6, TNF-α reduction)
- Inflammatory bowel disease pathway research
- Skin inflammation and wound healing studies
- Comparative studies with full-length α-MSH
Product Specifications
- Quantity: Per vial
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For laboratory research only. Not for human or animal consumption.
Stacey Brady verified owner
Fast delivery and product arrived in perfect shape.
Anonymous verified owner
Fast shipping, great quality.
Kyle verified owner
Good stuff.
Blaine Randolph verified owner
Great stuff.
Angel verified owner
Excellent experience from order to delivery.
Alex Spitler verified owner
Great product.
Bryan W. verified owner
Works like it should, with careful packaging.
Robert L. verified owner
My one stop shop for research compounds.