Product Details
IGF1-LR3 — Long Arginine Insulin-Like Growth Factor
IGF1-LR3 (Long Arginine 3 IGF-1) is an 83-amino acid synthetic analog of insulin-like growth factor 1, featuring a 13-amino acid N-terminal extension and an arginine substitution at position 3. These modifications dramatically reduce binding to IGF binding proteins (IGFBPs), resulting in a compound with approximately 2-3x the potency and significantly longer functional half-life compared to native IGF-1.
Mechanism of Action
IGF1-LR3 binds to the IGF-1 receptor (IGF-1R), a transmembrane tyrosine kinase receptor that activates both the PI3K/Akt/mTOR pathway (promoting protein synthesis and cell survival) and the Ras/MAPK pathway (promoting cell proliferation and differentiation). Because LR3 has minimal affinity for IGFBPs, a greater proportion of the peptide remains bioactive in circulation, providing enhanced and prolonged receptor stimulation compared to recombinant human IGF-1.
Research Applications
- IGF-1R signaling and mTOR pathway activation
- Muscle protein synthesis and hypertrophy research
- Cell proliferation and differentiation studies
- IGFBP interaction and bioavailability research
- Neuroprotective and neurogenesis investigations
Product Specifications
- Quantity: 1mg per vial
- Purity: ≥98% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For research purposes only. Not for human use or consumption.
Stacey Brady verified owner
Fast delivery and product arrived in perfect shape.
Anonymous verified owner
Fast shipping, great quality.
Kyle verified owner
Good stuff.
Blaine Randolph verified owner
Great stuff.
Angel verified owner
Excellent experience from order to delivery.
Alex Spitler verified owner
Great product.
Bryan W. verified owner
Works like it should, with careful packaging.
Robert L. verified owner
My one stop shop for research compounds.