Product Details
MOTS-C — Mitochondrial-Derived Peptide
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type-C) is a 16-amino acid peptide encoded within the mitochondrial genome — one of only a few known mitochondrial-derived peptides (MDPs). Its discovery has opened new frontiers in understanding how mitochondrial DNA communicates with the nuclear genome to regulate systemic metabolism.
Mechanism of Action
MOTS-C activates the AMPK pathway (5′ AMP-activated protein kinase), a master regulator of cellular energy homeostasis. Through AMPK activation, MOTS-C enhances glucose uptake, promotes fatty acid oxidation, and improves mitochondrial respiration. Research has shown that MOTS-C translocates to the nucleus under metabolic stress, where it directly regulates gene expression related to antioxidant response elements (ARE) through interaction with the NRF2 pathway.
Research Applications
- AMPK pathway activation and metabolic regulation
- Exercise mimetic and endurance physiology studies
- Insulin sensitivity and glucose metabolism research
- Mitochondrial-nuclear communication (retrograde signaling)
- Aging biomarker and longevity pathway investigations
- Metabolic stress response mechanisms
Product Specifications
- Quantity: 10-40mg per vial (select option)
- Purity: ≥98% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For research purposes only. Not for human use or consumption.
Stacey Brady verified owner
Fast delivery and product arrived in perfect shape.
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Fast shipping, great quality.
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Good stuff.
Blaine Randolph verified owner
Great stuff.
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Excellent experience from order to delivery.
Alex Spitler verified owner
Great product.
Bryan W. verified owner
Works like it should, with careful packaging.
Robert L. verified owner
My one stop shop for research compounds.