Product Details
Cagrilinitide — Long-Acting Amylin Receptor Agonist
Cagrilinitide is a long-acting acylated amylin analog designed for sustained receptor activation. Amylin is a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells, and plays a complementary role in postprandial glucose regulation. Cagrilinitide’s structural modifications — including acylation with a fatty acid chain — significantly extend its pharmacokinetic profile compared to native amylin.
Mechanism of Action
Cagrilinitide activates amylin receptors (AMY1, AMY2, AMY3), which are heterodimeric complexes of the calcitonin receptor (CTR) with receptor activity-modifying proteins (RAMPs). Activation of these receptors in the area postrema and hypothalamus modulates appetite signaling, slows gastric emptying, and suppresses postprandial glucagon secretion. The acylated structure enables albumin binding in circulation, providing a sustained duration of action suitable for extended research protocols.
Research Applications
- Amylin receptor signaling and RAMP biology
- Appetite regulation and satiety pathway studies
- Gastric motility and emptying rate research
- Postprandial glucagon suppression mechanisms
- Combination studies with incretin receptor agonists
- Beta-cell biology and islet hormone co-secretion
Product Specifications
- Quantity: 5mg per vial
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For research purposes only. Not for human use or consumption.
Stacey Brady verified owner
Fast delivery and product arrived in perfect shape.
Anonymous verified owner
Fast shipping, great quality.
Kyle verified owner
Good stuff.
Blaine Randolph verified owner
Great stuff.
Angel verified owner
Excellent experience from order to delivery.
Alex Spitler verified owner
Great product.
Bryan W. verified owner
Works like it should, with careful packaging.
Robert L. verified owner
My one stop shop for research compounds.