Product Details
CJC-1295 w/DAC — Long-Acting GHRH Analog
CJC-1295 with DAC (Drug Affinity Complex) is a synthetic tetrasubstituted analog of growth hormone-releasing hormone (GHRH 1-29) engineered for extended biological activity. The DAC modification — a maleimidopropionic acid linker conjugated to D-Ala at position 2 — enables covalent binding to serum albumin, extending the peptide’s functional half-life from minutes to approximately 6-8 days in preclinical models.
Mechanism of Action
CJC-1295 binds to GHRH receptors on anterior pituitary somatotrophs, activating the Gs/adenylyl cyclase/cAMP signaling cascade to stimulate GH gene transcription and secretion. The DAC modification creates a sustained-release profile: after administration, the reactive maleimido group forms a covalent bond with albumin’s Cys-34 residue, creating a circulating depot that provides continuous receptor stimulation over days rather than hours.
Research Applications
- Sustained GH secretion and pulsatility studies
- Pharmacokinetic modeling of albumin-conjugated peptides
- IGF-1 axis stimulation and downstream signaling
- Comparative studies with non-DAC GHRH analogs
- Somatotropic axis modulation in aging models
Product Specifications
- Quantity: 5mg per vial
- Purity: ≥98% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For research purposes only. Not for human use or consumption.
Stacey Brady verified owner
Fast delivery and product arrived in perfect shape.
Anonymous verified owner
Fast shipping, great quality.
Kyle verified owner
Good stuff.
Blaine Randolph verified owner
Great stuff.
Angel verified owner
Excellent experience from order to delivery.
Alex Spitler verified owner
Great product.
Bryan W. verified owner
Works like it should, with careful packaging.
Robert L. verified owner
My one stop shop for research compounds.